埃罗替尼

参考资料仅供科学研究，不可用于个人用途。

货号：BCP09267CAS号：183321-74-6纯度：99%

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CAS号	183321-74-6	货号	BCP09267
关联产品	183319-69-9（盐酸埃罗替尼）
中文名	埃罗替尼
英文名	Erlotinib
中文别名
英文别名	NSC 718781; R1415;R 1415;R-1415CP-358,774; CP-358774; CP358774; OSI-774; OSI 774; OSI774; Erlotinib free base;
SMILES
化学名称
分子式	C22H23N3O4	分子量	393.44
纯度	99%	配送	惯例下常温包邮
产品描述	Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.