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ABT-263(Navitoclax)
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No.BCP0010 
Product Name:ABT-263(Navitoclax) 
Synonyms:ABT 263 
Cas No.:923564-51-6 
Molecular Formula:C47H55ClF3N5O6S3 
Molecular Weight:974.61 
Purity:98% 
Apperarnce:yellow powder 

Surprise price for bulk quantity

 

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.ABT-263 (Navitoclax) is a potent orally bioavailable SMI that is structurally related to ABT-737. ABT-263 disrupts Bcl-2 - Bcl-XL interactions with pro-apoptotic proteins .

1, ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.Tse C et al, Cancer Res. 2008 May 1;68(9):3421-8.

2, Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Shoemaker AR, et al. Clin Cancer Res. 2008 Jun 1;14(11):3268-77.

3, ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo. Ackler S, et al,Mol Cancer Ther. 2008 Oct;7(10):3265-74.

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