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No.BCP001665 
Product Name:GSK126 
Cas No.:1346574-57-9 
Molecular Formula:C31H38N6O2 
Molecular Weight:526.67 
Purity:99% 
Apperarnce:白色粉末 
Supply ability:10G 

GSK126 is a highly potent and selective small molecule inhibitor of histone methyltransferase EZH2. It potently inhibits both wild-type and mutant EZH2 methyltransferase activity with similar potencies (Kiapp 0.5–3 nM), independent of substrate used, and is competitive with S-adenosylmethionine (SAM) and non-competitive with peptide substrates. GSK126 is highly selective against other methyltransferases and multiple other protein classes, even 150-fold more selective for the closest EZH1 (Kiapp 89 nM) and more than 1,000-fold selective for 20 other human methyltransferases, including both SET-domain-containing and non-SET domain-containing methyltransferases. It induced a 50% loss of H3K27me3 in both EZH2 wild-type and mutant DLBCL cell lines at nM concentrations independent of EZH2 mutation status. GSK126 can decrease global H3K27me3 levels and reactivate silenced PRC2 target genes. It effectively inhibits the proliferation of EZH2 mutant DLBCL cell lines, and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice. Pharmacological inhibition of EZH2 activity may provide a promising treatment for EZH2 mutant lymphoma.

Aztreonam(Azactam, Cayston)
Cefepime(Maxipime)
Natamycin(Pimaricin)
Pimecrolimus
pp60 c-src (521-533)
PTC-124(Ataluren)
Roscovitine
SRT1720
STF-62247
BTZ043
Cisplatin
CX-3543
FK-506
Malotilate
Odanacatib,MK0822
Akt-1-1,2
JNJ7706621
PD0332991
Ki16425
Tazarotenic Acid
ZM241385
Eltrombopag
Marbofloxacine
STA5326
betrixaban
FK866
GSK269962A
GW441756
Genipin
AZ-23
PHA848125
Calcitriol
MLN4924
Entecavir hydrate
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SF1126
4-(4-Chloro-6-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazin-2-yl)morpholine
SCH442416(SCH-442416)
Cyclen
Beta-Amyloid (1-42) human
AT-7519(HCI)
SNS-032(BMS387032)
Purvalanol B
PHA690509
AMG-47a
BI-D1870
AMG-Tie2-1
N2-[4-(Aminomethyl)phenyl]-5-fluoro-N4-phenylpyrimidine-2,4-diamine
GHRP-6 Acetate
GLP-1 (7-37) Acetate
Glucagon Hydrochloride(GlucaGen)
Gonadorelin
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DH 1011
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Azaphen
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Ko143
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CP101606
NSC 348884
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CGS21680
AH-001
VTP-27999 2,2,2-三氟乙酸盐
4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
N-[5-(4-Cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-3-pyridinecarboxamide
SPK601
Flavopiridol(Alvocidib)
Plerixafor
DMP-777
AZD5438
D-Mannitol(Osmitrol)
吴茱萸碱
Gastrodin(Gastrodine)
靛玉红; 2-(2-氧代-1H-吲哚-3-亚基)-1H-吲哚-3-酮
Lappaconite Hydrobromide
L-carnitine(Levocarnitine)
Naringin Dihydrochalcone(Naringin DC)
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LX1606;LX 1606;LX-1606
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VX-809
TAK700
Palmatine chloride
异甘草素
Sophocarpine
A 922500
JNJ 5207787
SSR 146977 hydrochloride
MM11253
UK5099
SB 223412;SB223412
Plerixafor;JM3100;AMD3100
SB408124
(3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
DZNep;NSC617989
Efavirenz
Garenoxacin mesylate hydrate
Garenoxacin
Zanamivir
X-Phos
Riboflavin (Vitamin B2)
Acetanilide (Antifebrin)
那高利特
RU58841
Nolatrexed dihydrochloride
长春布宁; (-)-象牙酮宁
安塞曲匹
托瑞司他
Torcetrapib
Carmoterol
Laninamivir
NXY059
6-硫鸟嘌呤; 2-氨基嘌呤-6(1H)-硫酮
卡巴他赛
T-705,T705
1Mps1-IN-1
KN-92
KN93
Kenpaullone
Bencynoate hydrochloride
磷酸奥司他韦; 达菲
FABP4 Inhibitor;BMS309403
Hydroxyprogesterone
Pluripotin
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QS11
多西他赛
WST-3
Saquinavir
ARRY-543
HU243
伏格列波糖
Methyl sterculate
MK-8245
URB754
TROX-1
GSK369796/GSK-369796
LY2814617
LY2886721
LY2322600
MK8245
SRT3109
RS-504393
SNS-032 HCl
AMG073,Cinacalcet hydrochloride
TPPB
TMS
LY3006072
LY2779357
反苯环丙胺盐酸盐
BMS-265246
LY2608204
MK1376
BMS-903710
CP154526/CP-154526
TG100801/TG-100801
GSK561679A/GSK-561679A
帕拉米韦
阿莫伦特
KM07978
Metanicotine/TC-2403-12/TC-2403/RJR-2403
SB222200
Org27759
KPT-185
(+/-)-双氮奋兴
6-氨基-7,9-二氢-2-(2-甲氧基乙氧基)-9-(苯甲基)-8H-嘌呤-8-酮
Diisopropylammonium dichloroacetate
GSK189254
Radezolid
Bedaquiline
BS-181
夫拉平度盐酸盐
PHA767491
R547
达比加群酯
Sch727965
AM580
CD437
3-吲哚丁酸
(3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrol-1-one
AKOS 92639
Calcipotriene
Deuterated Atazanivir
Dipyridamole
Docetaxel trihydrate
INCB8761
盐酸磺胺米隆; 氨苄磺胺盐酸盐; 4-氨甲基苯磺酰胺盐酸盐
Conivaptan
单宁酸
Deltarasin
替加环素
Retinoic acid
Zofenopril calcium
GSK1210151A
Zidovudine
(R)-4-((R)-1-(7-(3,4,5-trimethoxyphenyl)-1,6-naphthyridin-5-yloxy)ethyl)pyrrolidin-2-one hydrochlori
N-(4-fluorobenzyl)-5-(2-(dimethylamino)-N-methyl-2-oxoacetamido)-8-hydroxy-1,6-naphthyridine-7-carbo
Rifaximine
依曲韦林
Suvorexant
MOXONIDINE
LXR 623
Nicomol
9-氨基四氢吖啶
(R*, R*)-(±)-N-[5-[1-Hydroxy-2-[[ 2-(4-methoxyphenyl)-1-methylethyl]-(phenylmethyl)amino]ethyl]-2-(p
Orazamide
Benzhexol hydrochloride
Cidofovir/Vistide
Meropenem
PF429242
鲁拉西酮
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Terbinafine
Cefozopran
SVT40776
P005672 HCl
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宾达利
Quetiapine Fumarate
IKK-16
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Algestone acetophenide
Clobetasol propionate
6-Biopterin
Cyclosporin B
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Salidroside
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OC000459
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Verteporfin
瑞替加滨
Trilostane
16alpha-hydroxyprednisolone
地拉考昔
Rosuvastatin calcium
Budesonide
Fluocortolone
RR 82
8-methyl-1,4-dioxaspiro[4.5]dec-8-yl)-, 1,1-dimethylethyl ester
蓓萨罗丁
AZD6126
AG-L-5968
Doxapram
Doramectin
Darunavir
Epalrestat
Telmisartan
Lornoxicam
Landiolol hydrochloride
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Salmeterol xinafoate
Doxapram hydrochloride monohydrate
Neotame
Prilocaine hydrochloride
Medetomidine hydrochloride
Riociguat
CP-101606-27
蝶酸
Diacetonefructose
Buclizine
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Orlistat
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Oxacephem nucleus
TCN-201
Bayer18
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LY-315920
EPZ004777
Tyrphostin AG 879
GSK126
PD 168077 maleate
CP-945598
Methiopropamine
Thiacetazone
BIX 01294
AMD 3465 Hexahydrobromide
SNS-032
PB-22
Spiro[chroMan-2,4’-piperidine]
CID-2011756
Medetomidine
TG-02
GSK 2334470
Clofilium tosylate
阿佐昔芬
美格鲁特
CCG-41735
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JTT552/JTT-552
马沙骨化醇
ML 161
米卡芬净
非达霉素
绿卡色林盐酸盐
Ezatiostat
ICI-118551
INCB024360
HBX 41108
XCT-790
IOWH032
Lersivirine
SF1670(PTEN inhibitor)
LX1606
KW6002,KW-6002
拉扎贝胺
AZD-7545
JW55
PS 48
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UNC-1999
SEW01439
HTS02103
BTB01278
毛地黄毒苷配基
VCH-759
阿巴芬净
WAY362450
KM09665
RDR03570
细胞色素C 马心
A 205804
IOX2/IOX-2
GSK2801
CP-809101 hydrochloride
瑞沙托维
CX-6258
奥瑞布林
达比加群
diprophylline
ABT-492
BMS356103
GW2580
kb-NB142-70
SDZ 220-581
SYN-115
WF-11899A
GNF5837
Tasimelteon
RU-SKI43
VX-661
β-Alanine, N-[[3-[[(2E)-2-[[(3,5-diamino-6-chloro-2-pyrazinyl)carbonyl]imino]-1,3,8-triazaspiro[4.5]dec-8-yl]carbonyl]phenyl]sulfonyl]-, 2-(dipropylamino)-2-oxoethyl ester, butanedioate (1:?)
2-Pyridinecarboxamide, N-[3-[(3R)-5-amino-3-(difluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methyl-
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with 2-amino-2-methyl-N-[(1R)-2-[(4S,5R)-2-methyl-1-oxo-4-phenyl-2,7-diazaspiro[4.5]dec-7-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]propanamide (1:?)
CETP inhibitor
Z-VAD-FMK
1356331-63-9
2-Pyridinecarboxamide, 3-amino-6-methoxy-N-[(2S)-3,3,3-trifluoro-2-hydroxy-2-methylpropyl]-5-(trifluoromethyl)-
1H-Indole-4-carboxamide, N,N’-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-
Pyrido[4,3-d]pyrimidine, 5,6,7,8-tetrahydro-6-(6-methoxy-5-methyl-3-pyridinyl)-4-[(3S)-3-pyrrolidinyloxy]-
NITD609
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-[(1R,6S)-9-methyl-4-oxo-3,9-diazabicyclo[4.2.1]non-3-yl]-2-pyridinyl]amino]-
GSK-0660
AMD070
N-[(3R)-3-([1,1’-联苯]-4-氧基)-3-(4-氟苯基)丙基]-N-甲基甘氨酸
NBI-42902
(+)-JQ-1
R428
X-082
CJ-023423
10-脱乙酰基巴卡丁Ⅲ
BAY 11-7085
GSK2578999A
TPEN
GW4869
SG-2202
7-MAC
CHR-6494
GO-6976
GW844520
SGC0946
CY7
exherin
Cy5
TAK-785
LY2623091
LDN-192960
S0859
胸腺素 beta 4
拉氧头孢钠
苔藓抑素
GSK2606414
GSK-2565363
GSK-2578999
GSK-2611483A
GSK-2668871A
GSK-2835574B
GSK-2838232
GSK-2975112A
GSK-2975115A
GSK-2975119A
GSK-2975176A
GSK-2975177A
AM555S
TTP22
YS-49
Scriptaid
MK-886
Dapivirine
D-6413
KU14R
YM-90K hydrochloride
LDN-211904
BMS345541
BMS345541
林可霉素
delafloxacine
PF 8380
AM679
RCS-4
Vanoxerine
HC-030031
LVT derivative of Gemcitabine,Gemcitabine elaidate
INNO-206 HCl salt
IDH-C35
gamma-ketotriazole
GSK525762A
7-氨基头孢三嗪
CPI413
Carebastine
AMG-517
新利司他
Debacarb
盐酸去甲乌头碱
吡罗达韦
爱维莫潘
EPZ6438;E7438
UNC1215
2-(吡咯烷-1-基)苯基-1-戊酮
阿伐他汀钠
孕二烯二酮
EPZ-5676
LM-1532
GW-19292
pvp-2
GSK2578999
1422355-65-4
13626-46-5
NKP-608
GPI-1046
GSK 650394
Conduritol B Epoxide
Emricasan
RO 61-8048
Y-352,阿戈美拉汀杂质
PV-8
PFI-1
TMC435350
Bevirimat
辛伐他汀杂质
LDN-57444
SC-144
奈必洛尔
金雀异黄酮
艾沙康唑
D-氢化奎宁-1,4-酞嗪二醚;CB0672988
G-418 硫酸盐
西司他丁
AB-PINACA
Ki-16198
子囊霉素
艾捉非尼
Deferitrin
TAK 599
依普利酮
GSK2578215A
FV-100
MCC257
PA-824
埃博霉素C
Afoxolaner
SteMRegenin 1
瑞替加滨二盐酸盐
坎格雷洛
CPI-203
P005091;P5091
EMD-1214063
LY-2835219
SC-514
GSK-343
VUF11207
TBA-354
Cerpegin
地索苷
LCQ-908
Acotiamide
去氧肾上腺素
3-Deazaneplanocin A hydrochloride
SDZWAG994
LCL-161
Delamanid
P22077
IRAK 抑制剂 6
坎苯达唑
GK2578215A
EPI-743
NHWD-276
卡普瑞林
芬司匹利
MF-63
fub-pb22
MK6096
EPZ005687
ADRIAMYCINOL;RP-27706;RP27706
PluriSln 1
PR-619
PF-03394197
QNZ
乙莫克舍
Osteocalcin fragment 1-49 Human
安丝菌素 P 3
PST2744;PST-2744
PF 02367982
Way255348
BAY58-2667;BAY582667
Alvelestat
VE-822
PACMA-31
PF 4708671
TUG-770
特考韦瑞
艾托立宾
VX11e
PCI-27483
瑞波西汀甲磺酸盐
1-甲基-D-色氨酸
PD123319
Z-Gly-Leu-Phe-chloromethyl ketone
NSC 405020
大麻二酚
GANT61
5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone
巴马司他
SGI-7079
CPP-Lysine
4Μ8C
EUK-134
1-脱氧野尻霉素
曲格列汀琥珀酸盐
NSC687852
SCH54292
安丝菌素P-3
TP808
(-)-JQ-1
Fatostatin A
Cytochalasin D
SRPIN340
GSK-J2
TAK-475
GSK-J5
GSK-J1
GSK J4
UNC0642
bromosporine
Poziotinib
JIB-04
SGC-CBP30
I-CBP112
人牛吡啶APELIN-13
5FAB-PINACA
CPI-0610
BI-97C1
LG100268
RI-1
Rigosertib sodium
GF 109203X
Gas6
alisporivir
TCS 1102
C646
雷贝拉唑钠
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