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No.BCP0009 
Product Name:Abiraterone(CB-7598) 
Synonyms:17-(3-Pyridyl)androsta-5,16-dien-3beta-ol 
Cas No.:154229-19-3 
Molecular Formula:C24H31NO 
Molecular Weight:349.51 
Purity:98% 

 

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ABIRATERONE(CB-7598), a steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.In preclinical studies, ABIRATERONE(CB-7598) has demonstrated the ability to selectively inhibit the target enzyme (IC50 4 nM for hydroxylase), resulting in inhibition of testosterone production in both the adrenals and the testes. Clinical studies demonstrated that CYP17 blockade by ABIRATERONE(CB-7598) acetate is safe and has significant antitumor activity in CRPC (castration-resistant prostate cancer).In 2008, enrolment had commenced into a Phase I/II trial of CB7630 (ABIRATERONE acetate) in patients with advanced breast cancer.

Potter, G.A.; et al.; Novel steroidal inhibitors of human cytochrome P450(17alpha) (17alpha-hydroxylase-C17,20-lyase): Potential agents for the treatment of prostatic cancer. J Med Chem 1995, 38, 13, 2463.

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