Product Pathways
BCP0012 ABT-869(Linifanib)
ABT-869 is multi-targeted in that it is a potent inhibitor of all members of the VEGF and PDGF receptor families.
BCP0018 Axitinib
a small molecule tyrosine kinase inhibitor under development by Pfi
BCP0029 BIBF1120
BIBF 1120 is an indolinone derivative potently blocking VEGF receptor (VEGFR), PDGFR and FGFR kinase activity in enzymatic assays (IC50, 20-100 nmol/L).
BCP0119 Sorafenib Tosylate(Bay 43-9006)
Sorafenib (Bay 43-9006) is a novel bi-aryl urea compound that inhibits cell proliferation by targeting the ERK pathway and angiogenesis by targeting the receptor tyrosine kinases VEGFR-2 and PDGFR-ß and their associated signaling cascades.
BCP0123 Sunitinib Malate(Sutent)
Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.
BCP0034 Brivanib(BMS-540215)
A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to improve the aqueous solubility and oral bioavailability of the parent compound.
BCP0035 Brivanib alaninate(BMS-582664)
BMS-582664, also named brivanib alaninate, is the alaninate salt of a VEGFR2 inhibitor BMS-540215.
BCP0040 Cediranib (AZD2171)
Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM.
BCP0051 E7080
E7080 is the most potent dual inhibitor of VEGF-R3 tyrosine kinase (IC50=5.2 nM) as well as VEGF-R2 tyrosine kinase (IC50=4.0 nM) among those small-molecule inhibitors of VEGF-R kinases, such as sunitinib, sorafenib, and CEP-7055.
BCP0073 Masitinib
C-Kit, PDGFR and FGFR3 InhibitorKIT inhibitor, dose-dependently inhibited SCF-induced cell proliferation with an IC50 of 150 nM.
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