Granisetron

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP10022CAS No. ：109889-09-0Purity：98%

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CAS No.	109889-09-0	Cat. No.	BCP10022
Name	Granisetron
Synonyms
SMILES
Chemical Name
Formula	C18H21D3N4O	M. Wt	312.41
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT. in vivo: Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE(2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3). Both treatments were well tolerated, the most common adverse event being constipation .