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G749 Chemical Structure

G749

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP11201CAS No. ：1457983-28-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1457983-28-6 Cat. No. BCP11201
Name G749
Synonyms G-749;G 749;
SMILES
Chemical Name
Formula C25H25BrN6O2 M. Wt 521.41
Purity 98% Storage Store at 4-8°C
Description G-749 showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retained its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection. Furthermore, it displayed potent antileukemic activity in bone marrow blasts from AML patients regardless of FLT3 mutation status, including those with little or only minor responses to AC220 or PKC412. Oral administration of G-749 yielded complete tumor regression and increased life span in animal models.
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