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BLU9931 Chemical Structure

BLU9931

Data Sheet For research use only. Not for human use.
Cat. No. :BCP15296CAS No. :1538604-68-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1538604-68-0 Cat. No. BCP15296
Name BLU9931
Synonyms BLU-9931;BLU 9931;
SMILES
Chemical Name
Formula C26H22Cl2N4O3 M. Wt 509.38
Purity 98% Storage Store at 4-8°C
Description BLU9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor xenograft that overexpresses FGF19 mRNA but lacks FGF19 amplification. Approximately one third of patients with HCC whose tumors express FGF19 together with FGFR4 and its coreceptor klotho β (KLB) could potentially respond to treatment with an FGFR4 inhibitor.
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