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BPR1J-097 Chemical Structure

BPR1J-097

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP16866CAS No. ：1327167-19-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1327167-19-0 Cat. No. BCP16866
Name BPR1J-097
Synonyms BPR1J097; BPR1J-097; BPR1J 097; BPR1-J097; BPR1 J097; BPR1J097;
SMILES
Chemical Name
Formula C27H28N6O3S M. Wt 516.61
Purity 98% Storage Store at 4-8°C
Description BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities. BPR1J-097 may be useful in AML treatments.IC50 of BPR1J-097 required to inhibit FLT3 kinase activity ranged from 1 to 10 nM, and the 50% growth inhibition concentrations (GC(50)s) were 21?±7 and 46?±14 nM for MOLM-13 and MV4-11 cells, respectively. BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells. BPR1J-097 also showed favourable pharmacokinetic property and pronounced dose-dependent tumour growth inhibition and regression in FLT3-driven AML murine xenograft models.
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