Products

BCP01715's Information

CAS NO. 879085-55-9 structure
Product Name Vismodegib
Synonyms GDC-0449;GDC 0449;GDC0449
Formula C19H14Cl2N2O3S
Molecular Weight 421.31
Spec / Purity 98%
Supply Capacity can supply g scale
Product Description Vismodegib is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
Details GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 also blocks ABCG2, Pgp, and MRP1-important ABC transporters associated with MDR. GDC-0449 is a potent inhibitor of ABC transporters, ABCG2/BCRP and ABCB1/Pgp, and is a mild inhibitor of ABCC1/MRP1. In ABCG2-overexpressing HEK293 cells, GDC-0449 increase

Price Info Please inquire us for bulk quantity, thanks.
size Price Stock
5 G
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Maintained in stock
1 G
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Maintained in stock
100 MG
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Maintained in stock
50 MG
US$117.30
Maintained in stock

Quality Control
Batch No. File Type File Name
2014041701
LCMS
2014041701
NMR
0000
DATASHEET

PI3K/Akt/mTOR
Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
PARP/BET
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Integrase/CCR5
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway
Intermediate