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Navitoclax Chemical Structure

Navitoclax

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01724CAS No. :923564-51-6Purity:99%
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  • Chemical Properties&Biological Activity
CAS No. 923564-51-6 Cat. No. BCP01724
Name Navitoclax
Synonyms ABT-263;ABT 263;ABT263;
SMILES CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Chemical Name
Formula C47H55ClF3N5O6S3 M. Wt 974.61
Purity 99% Storage Store at 4-8°C
Description Navitoclax is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Navitoclax selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w, which are frequently overexpressed in a wide variety of cancers, including those of the lymph, breast, lung, prostate, and colon, and are linked to tumor drug resistance. Inhibition of these apoptosis suppressors prevents their binding to the apoptotic effectors Bax and Bak proteins, thereby triggering apoptotic processes in cells overexpressing Bcl-2, Bcl-XL, and Bcl-w. This eventually reduces tumor cell proliferation.
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