AT9283 (2S)-2-Hydroxypropanoic acid salt
Data Sheet
For research use only. Not for human use.
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| CAS No. | 896466-76-5 | Cat. No. | BCP01732 |
| Name | AT9283 (2S)-2-Hydroxypropanoic acid salt | ||
| Synonyms | AT-9283;AT 9283;AT9283; | ||
| SMILES | O=C(NC1CC1)NC2=CNN=C2C3=NC(C=C4)=C(C=C4CN5CCOCC5)N3.O=C(O)[C@](C)O | ||
| Chemical Name | |||
| Formula | C22H29N7O5 | M. Wt | 471.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AT9283 is a multikinase inhibitor, is also a small-molecule inhibitor of several kinases with potential antineoplastic activity. Multikinase inhibitor AT9283 binds to and inhibits Aurora kinases A and B, JAK2 (Janus kinase 2) and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis; JAK2 is a kinase that transduces signals from the single chain and IL-3 cytokine receptor families, and from the IFN-gamma receptors; BCR-ABL is a fusion protein with tyrosine kinase activity that is commonly found in CML. | ||
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