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BCP01741's Information

CAS NO. 414864-00-9/866323-14-0 structure
Product Name Belinostat
Synonyms PXD101;PX105684;PXD-101;PXD 101;PX-105684,贝利司他
Formula C15H14N2O4S
Molecular Weight 318.35
Spec / Purity 98%
Supply Capacity can supply g scale
Product Description Belinostat also known as PXD101 is a HDAC inhibitor with IC50 of 27 nM.
Details Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells, which are cisplatin and doxorubicin-resistant derivatives of A2780 cells. Belinostat could induce apoptosis through PARP cleavage and acetylation of histones H3/H4. Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase and increase in G2-M phase.The growth inhibitory activity of belinostat on cell lines is not strongly influenced by the multidrug-resistant phenotype, whereas the activity of docetaxel is clearly affected. Belinostat could enhance the growth inhibitory activity of docetaxel or carboplatin in OVCAR-3 and A2780 cells. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA.

Price Info Please inquire us for bulk quantity, thanks.
size Price Stock
1 G
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Typically in stock
50 MG
US$163.20
Typically in stock
100 MG
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Typically in stock
500 MG
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Typically in stock

Quality Control
Batch No. File Type File Name
0000
DATASHEET
2013120301
COA
2013120301
NMR
2013120301
LCMS
2013120301
NMR
2014080702
NMR
2014080702
LCMS
2015031604
LCMS
2015031604
NMR

PI3K/Akt/mTOR
Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
PARP/BET
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Integrase/CCR5
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway
Intermediate