SB203580

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01763CAS No. ：152121-47-6Purity：98%

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CAS No.	152121-47-6	Cat. No.	BCP01763
Name	SB203580
Synonyms	SB-203580;SB 203580;RWJ 64809;
SMILES
Chemical Name
Formula	C21H16FN3OS	M. Wt	377.43
Purity	98%	Storage	Store at 4-8°C
Description	SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3–5 μm. SB203580 also inhibits IL-2-induced p70S6 kinase activation, although the concentration required is slightly higher with an IC50 above 10 μm. SB203580 also inhibits the activity of PDK1 in a dose-dependent manner with an IC50 in the 3–10 μm range. SB203580 inhibits p38-MAPK stimulation of MAPKAPK2 with an IC50 of approximately 0.07 μM, whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM. SB203580 at higher concentrations activates the ERK pathway, which subsequently enhances NF-κB transcriptional activity. SB203580 induces autophagy in human hepatocellular carcinoma (HCC) cells.