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Sorafenib Chemical Structure

Sorafenib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01767CAS No. ：284461-73-0Purity：98%
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  • Publications Citing of Biochempartner's Sorafenib
Int J Nanomedicine. 2015; 10: 6185–6198. Oncotarget. 2016 Jun 14; 7(24): 36767–36782.
Int J Nanomedicine. 2016; 11: 2329–2343. Nanomicro Lett. 2021 Dec; 13: 6.
Nanomicro Lett. 2021 Dec; 13: 6. Cell Death Dis. 2017 May; 8(5): e2766.
  • Chemical Properties&Biological Activity
CAS No. 284461-73-0 Cat. No. BCP01767
Name Sorafenib
Synonyms BAY 439006; BAY439006; BAY-439006;BAY 43-9006;
SMILES O=C(NC(C=C1)=CC=C1OC2=CC(C(NC)=O)=NC=C2)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Chemical Name
Formula C21H16ClF3N4O3 M. Wt 464.83
Purity 98% Storage Store at 4-8°C
Description Sorafenib is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.
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H-NMR HPLC
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