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BCP01769's Information

CAS NO. 162635-04-3 structure
Product Name Temsirolimus
Synonyms CCI-779;CCI779;NSC 683864;NSC-683864
Formula C56H87NO16
Molecular Weight 1030.29
Spec / Purity 98%
Supply Capacity can supply g scale
Product Description Temsirolimus (CCI-779, NSC 683864) is a specific mTOR inhibitor with IC50 of 1.76 μM in a cell-free assay.
Details In the absence of FKBP12, Temsirolimus potently inhibits mTOR kinase activity with IC50 of 1.76 μM, similar to that of rapamycin with IC50 of 1.74 μM. Temsirolimus treatment at nanomolar concentrations (10 nM to <5 μM) displays a modest and selective antiproliferative activity via FKBP12-dependent mechanism, but can completely inhibit the proliferation of a broad panel of tumor cells at low micromolar concentrations (5-15 μM), involving FKBP12-independent suppression of mTOR signaling. Temsirolimus treatment at micromolar but not nanomolar concentrations (20 μM) causes a marked decline in global protein synthesis and disassembly of polyribosomes, accompanied by rapid increase in the phosphorylation of translation elongation factor eEF2 and the translation initiation factor eIF2A. Temsirolimus inhibits the phosphorylation of ribosomal protein S6, more potently in PTEN-positive DU145 cells than in PTEN-negative PC-3 cells, and inhibits cell growth and clonogenic survival of both cells in a concentration-dependent manner. Temsirolimus (100 ng/mL) potently inhibits proliferation and induces apoptosis in primary human lymphoblastic leukemia (ALL) cells.

Price Info Please inquire us for bulk quantity, thanks.
size Price Stock
5 MG
US$84.66
Typically in stock
500 MG
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Typically in stock
100 MG
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Typically in stock
50 MG
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Typically in stock
10 MG
US$135.83
Typically in stock

Quality Control
Batch No. File Type File Name
2014040408
LCMS
2014040408
LCMS
2014040408
NMR
2014040408
COA
0000
DATASHEET
2014071408
LCMS
2016061402
NMR
2017021604
NMR
2016061402
LCMS

PI3K/Akt/mTOR
Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
PARP/BET
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Integrase/CCR5
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway
Intermediate