Canertinib New
Data Sheet
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| CAS No. | 267243-28-7 | Cat. No. | BCP01790 |
| Related Products | 289499-45-2（Canertinib dihydrochloride） | ||
| Name | Canertinib | ||
| Synonyms | PD-183805;CI1033;CI-1033;CI 1033;PD 183805;PD183805; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H25ClFN5O3 | M. Wt | 485.94 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Canertinib, also known as CI1033 and PD183805, is a potent ErbB inhibitor for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate for OATP1B3. Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can lead to transporter mediated drug-drug interactions. Also, canertinib is not an inhibitor of OATP-1B1 or OATP-1B3 transporter. | ||
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