Fingolimod HCl
Data Sheet
For research use only. Not for human use.
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| CAS No. | 162359-56-0 | Cat. No. | BCP01808 |
| Name | Fingolimod HCl | ||
| Synonyms | Fingolimod;Gilenia;FTY720; FTY-720; FTY 720;Fingolimod hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H33NO2.HCl | M. Wt | 343.93 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720.Medium and high-dose FTY720-P also enhances the levels of TGF-β1. TGF-β1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group. | ||
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