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JNJ-38877605 Chemical Structure

JNJ-38877605

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01812CAS No. :943540-75-8Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 943540-75-8 Cat. No. BCP01812
Name JNJ-38877605
Synonyms JNJ38877605;JNJ 38877605;
SMILES
Chemical Name
Formula C19H13F2N7 M. Wt 377.35
Purity 98% Storage Store at 4-8°C
Description JNJ-38877605 shows more than 600-fold selectivity for c-Met compared with more than 200 other diverse tyrosine and serine-threonine kinases and also potently inhibits HGF-stimulated and constitutively activated c-Met phosphorylation in vitro. In EBC1, GTL16, NCI-H1993, and MKN45 cells, JNJ-38877605 (500 nM) leads to a significant reduction of phosphorylation of Met and RON, another key player in invasive growth. A recent study shows that JNJ-38877605 is involved in modulating secretion of IL-8, GROa, uPAR and IL-6 in GTL16 cells.
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