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NVP-CGM097 Chemical Structure

NVP-CGM097

Data Sheet For research use only. Not for human use.
Cat. No. :BCP18308CAS No. :1313363-54-0Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1313363-54-0 Cat. No. BCP18308
Name NVP-CGM097
Synonyms CGM097;CGM 097;CGM-097;NVP CGM097;
SMILES
Chemical Name
Formula C38H47ClN4O4 M. Wt 659.26
Purity 98% Storage Store at 4-8°C
Description Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.
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