RS-102895 hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1173022-16-6 | Cat. No. | BCP18408 |
| Name | RS-102895 hydrochloride | ||
| Synonyms | RS-102895 HCl; RS102895 HCl;RS 102895 HCl;RS 102895 hydrochloride;RS102895 hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H22ClF3N2O2 | M. Wt | 426.86 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vitro: Transfections of mMCP-1 and CCR2 siRNA increased human MCP-1 levels and inhibited CCR2 expression, respectively. HG-induced ECM protein expression and TGF-beta1 levels were significantly attenuated by mMCP-1, CCR2 siRNA, and RS102895 (P < 0.05). Monocytic cell migration in response to hBD-3 was inhibited by cross-desensitization with MCP-1 and the specific CCR2 inhibitor, RS102895 in vivo: Fracture healing in MCP-1-/- and CCR2-/- mice was delayed compared with WT mice on day 21. Administration of RS102895 in the early, but not in the late phase, caused delayed fracture healing. Transplantation of WT-derived graft into host MCP-1-/- mice significantly increased new bone formation in the bone graft exchange models | ||
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