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PF-562271 Chemical Structure

PF-562271

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01852CAS No. ：717907-75-0Purity：98%
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  • Publications Citing of Biochempartner's PF-562271
PLoS One. 2016; 11(3): e0150567.
  • Chemical Properties&Biological Activity
CAS No. 717907-75-0 Cat. No. BCP01852
Related Products 939791-38-5（PF-562271 benzenesulfonate） 939791-41-0（PF-562271 HCl）
Name PF-562271
Synonyms PF562271;PF00562271;
SMILES
Chemical Name
Formula C21H20F3N7O3S M. Wt 507.49
Purity 98% Storage Store at 4-8°C
Description PF-562271 binds in the ATP-binding cleft of FAK, forming two of the three “canonical” H-bonds between the inhibitor and main-chain atoms in the kinase hinge region. PF-562271 is potent in an inducible cell-based assay measuring phospho-FAK with IC50 of 5 nM. PF-562271 (3.3 μM) results in G1 arrest of PC3-M cells. PF-562271 (1 nM) blocks bFGF-stimulated blood vessel angiogenesis as performed in chicken chorioallantoic membrane assays. PF-262271 potently blocks blood vessel sprouting without detectable changes in vascular leakage. PF-562271 (250 nM) results in complete inhibition of collective A431 cell invasion into collagen gels.
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LCMS H-NMR H-NMR HPLC
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