Varespladib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 172732-68-2 | Cat. No. | BCP01854 |
| Name | Varespladib | ||
| Synonyms | LY-315920;LY 315920;LY315920; A-002; A002; A 002;LY 333013;LY-333013;LY333013; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H20N2O5 | M. Wt | 380.4 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY315920 exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50 of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. In BAL cells challenged with human sPLA2, LY315920 at doses ranging from 0.1 μM–3 μM reduces the formation of thromboxane mediated by human sPLA2 in a concentration-dependent manner with an IC50 of approximately 0.8 μM. In human conjunctival epithelial cell line (HCjE), LY315920 (10 μM) significantly inhibits all-trans-retinoic acid (RA) -induced membrane-associated mucin MUC16 expression by 100% at 24 hours and 99% at 48 hours. | ||
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