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Ivacaftor Chemical Structure

Ivacaftor

Data Sheet For research use only. Not for human use.
Cat. No. :BCP01857CAS No. :873054-44-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 873054-44-5 Cat. No. BCP01857
Name Ivacaftor
Synonyms VX-770;VX770;VX 770;Kalydeco;
SMILES O=C(C1=CNC2=C(C=CC=C2)C1=O)NC3=CC(O)=C(C(C)(C)C)C=C3C(C)(C)C
Chemical Name
Formula C24H28N2O3 M. Wt 392.49
Purity 98% Storage Store at 4-8°C
Description Ivacaftor, also known as VX-770, is a drug used to treat cystic fibrosis in people with certain mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, who account for 4–5% cases of cystic fibrosis, and is included in a combination drug, lumacaftor/ivacaftor, which is used to treat people with cystic fibrosis who have the F508del mutation in CFTR. Ivacaftor is a "potentiator" of CFTR, meaning it increases the probability that the defective channel will be open and allow chloride ions pass through the channel pore.
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