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CYC-116 Chemical Structure

CYC-116

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01887CAS No. ：693228-63-6Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 693228-63-6 Cat. No. BCP01887
Name CYC-116
Synonyms CYC116;CYC 116;
SMILES
Chemical Name
Formula C18H20N6OS M. Wt 368.46
Purity 98% Storage Store at 4-8°C
Description The most Aurora-selective CYC116 shows inhibitory effect on Aurora A and B kinases 50-fold more potently than any of the CDKs assayed.CYC116 is initially screened against a panel of human leukemia and solid tumor cell lines using an MTT antiproliferative assay. The results show that CYC116 has broad-spectrum antitumor activity and shows specific cytotoxicity against the acute myelogenous leukemia cell line MV4-11 with IC50 of 34 nM.In addition, anti-proliferative activity of CYC116 is found to be associated with Aurora A and B modulation such as, inhibition of Aurora autophosphorylation, reduction of histone H3 phosphorylation, polyploidy, followed by cell death, resulting from a failure in cytokinesis.
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