PI-103

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01923CAS No. ：371935-74-9Purity：98%

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CAS No.	371935-74-9	Cat. No.	BCP01923
Related Products	371935-79-4（PI-103 Hydrochloride） PI-103（PI-103 hydrobromide）
Name	PI-103
Synonyms	PI 103;PI103;
SMILES
Chemical Name
Formula	C19H16N4O3	M. Wt	348.36
Purity	98%	Storage	Store at 4-8°C
Description	PI-103 potently inhibits both the rapamycin-sensitive (mTORC1) and rapamycin-insensitive (mTORC2) complexes of the protein kinase mTOR. PI-103 inhibits constitutive and growth factor-induced PI3K/Akt, as well as mTORC1 activation. In blast cells, PI-103 inhibits leukemic proliferation, the clonogenicity of leukemic progenitors and induces mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 inhibits p110α >200-fold more potently than p110β. PI-103 also potently blocks production of PI(3,4)P2 and PIP3 in adipocytes and PIP3 in myotubes.PI-103 inhibits phosphorylation of Akt with an IC95 100-fold lower than that for LY294002. Strikingly, PI-103 completely protects animals from insulin-stimulated decline in blood glucose. PI-103 has additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells.