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PLX-8394 Chemical Structure

PLX-8394

Data Sheet For research use only. Not for human use.
Cat. No. :BCP19619CAS No. :1393466-87-9Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1393466-87-9 Cat. No. BCP19619
Name PLX-8394
Synonyms PLX 8394;PLX8394;Plixorafenib;
SMILES O=C(C1=C(F)C(NS(=O)(N2CC[C@@H](F)C2)=O)=CC=C1F)C3=CNC4=C3C=C(C=N4)C5=CN=C(C6CC6)N=C5
Chemical Name
Formula C25H21F3N6O3S M. Wt 542.53
Purity 98% Storage Store at 4-8°C
Description PLX8394 is an orally bioavailable inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential antineoplastic activity. PLX8394 appears to selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, which may subsequently inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be effective against tumors that express multiple mutated forms of the kinase and may be an effective therapeutic agent for tumors that are resistant to other BRAF inhibitor therapies that are specific for the BRAF V600E mutant.
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