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AS-605240 Chemical Structure

AS-605240

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02097CAS No. ：648450-29-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 648450-29-7 Cat. No. BCP02097
Name AS-605240
Synonyms AS605240;AS 605240;
SMILES
Chemical Name
Formula C12H7N3O2S M. Wt 257.27
Purity 98% Storage Store at 4-8°C
Description AS-605240 is an ATP-competitive PI3Kγ inhibitor, with Ki values of 7.8 nM. AS-605240 is isoform-selective, for AS-605240 also inhibits PI3Kα, β, and δ, with IC50 of 60, 270, and 300 nM, respectively. AS-605240 inhibits C5a-mediated PKB phosphorylation with IC50 of 90 nM. In bone marrow-derived monocytes (BMDMs), AS-605240 (1 μM) blocks MCP-1- or CSF-1-induced PKB phosphorylation. At SC-CA1 synapses in mice, AS-605240 (100 nM) eliminates NMDAR LTD, without affecting mGluR LTD, depotentiation, and LTP.
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LCMS H-NMR
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