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AZD8055 Chemical Structure

AZD8055

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02171CAS No. :1009298-09-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1009298-09-2 Cat. No. BCP02171
Name AZD8055
Synonyms AZD-8055;AZD 8055;CCG-168;CCG168;CCG 168;
SMILES
Chemical Name
Formula C25H31N5O4 M. Wt 465.56
Purity 98% Storage Store at 4-8°C
Description AZD8055 shows low activity (~1,000-fold) against all PI3K isoforms (α, β, γ, δ) and other members of the PI3K-like kinase family (ATM and DNA-PK). AZD8055 inhibits the phosphorylation of mTORC1 (p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2 (Akt) and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055, resulting in significant inhibition of cap-dependent translation. AZD8055 potently inhibits proliferation in U87MG, A549 and H838 cells with IC50 of 53, 50 and 20 nM, respectively. AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells.AZD8055 decreases AML blast cell proliferation and cell cycle progression, reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells. AZD8055 indicates inhibitory against the pediatric preclinical testing program (PPTP) cell lines with IC50 of 24.7?nM and indu
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