CP-466722

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02229CAS No. ：1080622-86-1Purity：98%

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CAS No.	1080622-86-1	Cat. No.	BCP02229
Name	CP-466722
Synonyms	CP466722;CP 466722;
SMILES
Chemical Name
Formula	C17H15N7O2	M. Wt	349.35
Purity	98%	Storage	Store at 4-8°C
Description	In vitro, CP-466722 is identified as a potential inhibitor to decrease the activity of purified ATM kinase to phosphorylate GST-p53(1–101) substrate. In addition, CP-466722 also shows the inhibitory activities against abl and src kinases.In HeLa cells, CP-466722 at doses of 6μM, results in the inhibition in ATM-dependent phosphorylation by reversibly inhibiting ionizing radiation (IR)-induced ATM kinase activity. Besides, ATM-dependent p53 induction is also inhibited by CP-466722 in MCF-7 human breast cancer cells and primary and immortalized diploid human fibroblasts.In response to IR, CP-466722 increased proportion of cells with G2/M DNA content and reduces proportion of cells with G1-phase DNA content in HeLa cells.Transient exposure to CP-466722 for a period of 4 hours sensitizes HeLa cells to IR without affecting cell plating nor cell viability.