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Ruxolitinib Chemical Structure

Ruxolitinib

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02424CAS No. :941678-49-5Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 941678-49-5 Cat. No. BCP02424
Related Products 1092939-17-7(Ruxolitinib phosphate)
Name Ruxolitinib
Synonyms INCB 018424;INCB018424;INCB-018424; INC 424; INC424; INC-424; INCB18424; INCB 18424; INCB-18424;
SMILES C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Chemical Name
Formula C17H18N6 M. Wt 306.36
Purity 98% Storage Store at 4-8°C
Description Ruxolitinib is an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.
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