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GSK1059615 Chemical Structure

GSK1059615

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02498CAS No. ：958852-01-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 958852-01-2 Cat. No. BCP02498
Name GSK1059615
Synonyms GSK-1059615;GSK 1059615;
SMILES
Chemical Name
Formula C18H11N3O2S M. Wt 333.36
Purity 98% Storage Store at 4-8°C
Description The pyridinylquinoline derivative GSK1059615 is a novel, ATP-competitive, and reversible inhibitor of the class I family of PI3Ks. GSK1059615 inhibits PI3K signaling, induces G1 arrest and apoptosis, especially in breast tumor cells.Data summarized in another review also shows that GSK1059615 inhibits PI3Kα, β, γ and δ, with Ki of 0.42 nM, 0.6 nM, 0.47 nM and 1.7 nM, respectively. Another report shows that GSK1059615 inhibits PI3Kα with IC50 of 2 nM. In T47D and BT474 cancer cells, GSK1059615 inhibits the phosphorylation of Akt at S473, with IC50 of 40 nM.
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