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JTC-801 HCl Chemical Structure

JTC-801 HCl

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02544CAS No. ：244218-51-7Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 244218-51-7 Cat. No. BCP02544
Name JTC-801 HCl
Synonyms JTC-801 hydrochloride;JTC-801; JTC 801; JTC801;
SMILES
Chemical Name
Formula C26H25N3O2.HCl M. Wt 447.96
Purity 98% Storage Store at 4-8°C
Description JTC-801 displays about 12.5-, 129-, and 1055-fold selectivity for ORL1 receptor (Ki = 8.2 nM) over μ-, κ-, and δ-opioid receptors, respectively. JTC-801 does not inhibit forskolin-stimulated cyclic AMP accumulation in human ORL1 receptor-expressing HeLa cells, but it prevents nociceptin-induced inhibition of cyclic AMP accumulation, indicating that JTC-801 possesses full antagonistic activity.In rat cerebrocortical membrane, JTC-801 inhibits ORL1 receptor with IC50 of 472 nM and μ-receptor with IC50 of 1831 nM. JTC-801 completely antagonizes the suppression of nociceptin on forskolin-induced accumulation of cyclic AMP with IC50 of 2.58 μM in HeLa cells expressing ORL1 receptor.
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H-NMR HPLC H-NMR HPLC
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