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AZD-8931 Chemical Structure

AZD-8931

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02835CAS No. ：848942-61-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 848942-61-0 Cat. No. BCP02835
Name AZD-8931
Synonyms AZD8931;AZD 8931;Sapitinib;
SMILES
Chemical Name
Formula C23H25ClFN5O3 M. Wt 473.93
Purity 98% Storage Store at 4-8°C
Description AZD8931 shows different potency to NSCLC and SCCHN cell lines. AZD8931 has high sensitivity to PC-9 cells (EGFR activating mutation) with GI50 of 0.1 nM and low activity to NCI-1437 cells with GI50 above 10 μM. AZD8931 exhibits more potency against phospho-EGFR, phospho-erbB2 and phospho-erbB3 than either lapatinib or gefitinib in PE/CA-PJ41, PE/CA-PJ49, DOK and FaDu cells.
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