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PF-03814735 Chemical Structure

PF-03814735

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02851CAS No. ：942487-16-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 942487-16-3 Cat. No. BCP02851
Name PF-03814735
Synonyms PF 03814735;PF03814735;
SMILES
Chemical Name
Formula C23H25F3N6O2 M. Wt 474.48
Purity 98% Storage Store at 4-8°C
Description In intact cells, the inhibitory activity of PF-03814735 on the Aurora1 and Aurora2 kinases reduces levels of phospho-Aurora1 (Thr 232, a sensitive marker of Aurora1 activity, with IC50 ~ 20 nM), phosphohistone H3 (with IC50 ~ 50 nM), and phospho-Aurora2 (with IC50 ~150 nM). PF-03814735 produces a block in cytokinesis, resulting in inhibition of cell proliferation and the formation of polyploid multinucleated cells. A recent research indicates small cell lung cancer (SCLC) and, to a lesser extent, colon cancer lines are very sensitive to PF-03814735. The status of the Myc gene family and retinoblastoma pathway members significantly correlates with the efficacy of PF-03814735.
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