Cladribine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02868CAS No. ：4291-63-8Purity：98%

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CAS No.	4291-63-8	Cat. No.	BCP02868
Name	Cladribine
Synonyms	Leustatin;2-Chloro-2-deoxyadenosine;
SMILES
Chemical Name
Formula	C10H12ClN5O3	M. Wt	285.69
Purity	98%	Storage	Store at 4-8°C
Description	Cladribine exerts remarkable activity in hairy cell leukemia (HCL), a chronic B-cell lymphoproliferative disorder, producing prolonged complete remissions. Cladribine induces accumulation of DNA strand breaks, and subsequently activates the tumor suppressor p53 in lymphocytes. Cladribine may modulate STAT3 activity in MM cells. Cladribine inhibits proliferation/survival of U266, RPMI8226 and MM1.S cells in a dose-dependent manner. While U266 is the least sensitive cell line, MM1.S is the most sensitive one to cladribine. Treatment with cladribine gradually increases the percentage of cells in the G1 phase of the cell cycle and reduces the percentage of cells in S phase. Cladribine appears to increase G2-M phase in U266 cells upon 24 hour-treatment. A dose-dependent increase in apoptosis induced by cladribine is seen in both RPMI8226 and MM1.S cells. Treatment with cladribine at 0.2 μM dramatically induces activation of caspase-3, -8, and -9 and PARP cleavage in a time-dependent manner