PAC-1

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02892CAS No. ：315183-21-2Purity：98%

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CAS No.	315183-21-2	Cat. No.	BCP02892
Name	PAC-1
Synonyms	PAC1;PAC 1;Procaspase activating compound 1;
SMILES
Chemical Name
Formula	C23H28N4O2	M. Wt	392.49
Purity	98%	Storage	Store at 4-8°C
Description	PAC-1 activates procaspase-7 in a less efficient manner with EC50 of 4.5 μM. Elevated caspase 3 level in cancer cell lines allows PAC-1 to selectively induce apoptosis in a manner proportional to procaspase-3 concentration with IC50 of 0.35 μM for NCI-H226 cells to ~3.5 μM for UACC-62 cells. PAC-1 induces apoptosis in the primary cancerous cells with IC50 values of 3 nM to 1.41 μM, more potently than in the adjacent noncancerous cells with IC50 of 5.02 μM to 9.98 μM, which is also directly related to the distinct procaspase-3 concentration.PAC-1 activates procaspase-3 by chelating zinc ions, thus relieving the zinc-mediated inhibition and allowing procaspase-3 to auto-activate itself to caspase-3.PAC-1 is capable to induce cell death in Bax/Bak double-knockout cells and Bcl-2 and Bcl-xL-overexpressing cells with the same efficacy as its wild-type counterpart in a delayed manner. PAC-1 induces cytochrome c release in a caspase-3 independent manner, which subsequently triggers downstream