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Publications Citing of Biochempartner's Belnacasan
| CAS No. | 273404-37-8 | Cat. No. | BCP02893 |
| Name | Belnacasan | ||
| Synonyms | VX-765;VX 765;VX765; | ||
| SMILES | CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl | ||
| Chemical Name | |||
| Formula | C24H33ClN4O6 | M. Wt | 508.99 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. | ||
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