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Tiotropium Bromide hydrate Chemical Structure

Tiotropium Bromide hydrate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02924CAS No. :139404-48-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 139404-48-1 Cat. No. BCP02924
Name Tiotropium Bromide hydrate
Synonyms Spiriva;
SMILES
Chemical Name
Formula C19H22NO4S2.Br.xH2O M. Wt 490.43
Purity 98% Storage Store at 4-8°C
Description Tiotropium bromide is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease. Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against choliergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) . Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but mor
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