KX2-391 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1038395-65-1 | Cat. No. | BCP03485 |
| Name | KX2-391 dihydrochloride | ||
| Synonyms | KX2-391 2HCl; Tirbanibulin dihydrohcloride; | ||
| SMILES | C1COCCN1CCOC2=CC=C(C=C2)C3=CN=C(C=C3)CC(=O)NCC4=CC=CC=C4.Cl.Cl | ||
| Chemical Name | |||
| Formula | C26H29N3O3.2(HCl) | M. Wt | 504.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KX2-391 is a Src inhibitor that is directed to the Src substrate pocket. KX2-391 shows steep dose-response curves against Huh7 (GI 50 = 9 nM), PLC/PRF/5 (GI 50 = 13 nM), Hep3B (GI 50 = 26 nM), and HepG2 (GI 50 = 60 nM), four hepatic cell cancer (HCC) cell lines.KX2-391 is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. KX2-391 is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively. | ||
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