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BGT226 Chemical Structure

BGT226

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP03599CAS No. ：1245537-68-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1245537-68-1 Cat. No. BCP03599
Name BGT226
Synonyms NVP-BGT226;NVP-BGT 226;NVP BGT 226; BGT 226; BGT-226;
SMILES
Chemical Name
Formula C28H25F3N6O2.C4H4O4 M. Wt 650.6
Purity 98% Storage Store at 4-8°C
Description In a xenografted animal model, NVP-BGT226 significantly delays tumor growth in a dose-dependent manner, along with suppressed cytoplasmic expression of p-p70 S6 kinase and the presence of autophagosome formation. NVP-BGT226 inhibits tumor growth in a dose-dependent manner in a FaDu cell xenografted mouse model. Oral administration of NVP-BGT226 at 2.5 and 5 mg/kg for 3 weeks causes 34.7% and 76.1% reduction of the tumor growth on day 21, respectively (compared with control). NVP-BGT226 displays comparable inhibition against tumor growth to rapamycin. The final volume of both groups is significantly smaller than those treated with LY294002 (a PI3K inhibitor) or the control.
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