WP1066 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 857064-38-1 | Cat. No. | BCP04209 |
| Name | WP1066 | ||
| Synonyms | WP-1066; WP 1066; | ||
| SMILES | CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N | ||
| Chemical Name | |||
| Formula | C17H14BrN3O | M. Wt | 356.22 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | WP1066 is a Stat3 inhibitor and JAK2 inhibitor. WP1066 is also a novel analogue of the JAK2 inhibitor AG490, in JAK2 V617F-positive erythroleukemia HEL cells and in blood cells from patients with polycythemia vera. WP1066 significantly inhibited JAK2 and its downstream signal transducer and activator of transcription-3, signal transducer and activator of transcription-5, and extracellular signal-regulated kinase-1/2 pathways in a dose- and time-dependent manner. WP1066 is active both in vitro and ex vivo and should be further developed for the treatment of neoplasms expressing the JAK2 V617F mutation. | ||
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