PF670462
Data Sheet
For research use only. Not for human use.
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| CAS No. | 950912-80-8 | Cat. No. | BCP04305 |
| Name | PF670462 | ||
| Synonyms | PF 670462;PF-670462; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C19H20FN5.2HCl | M. Wt | 410.32 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF-670462 has been proved to be both a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations; in transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo. | ||
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