HSP-990
Data Sheet
For research use only. Not for human use.
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| CAS No. | 934343-74-5 | Cat. No. | BCP04758 |
| Name | HSP-990 | ||
| Synonyms | NVP-HSP990; HSP990; NVPHSP990; HSP 990; NVP HSP990; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H18FN5O2 | M. Wt | 98% |
| Purity | 379.38762 | Storage | Store at 4-8°C |
| Description | HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. | ||
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