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c-Kit-IN-1 Chemical Structure

c-Kit-IN-1

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP05207CAS No. ：1225278-16-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1225278-16-9 Cat. No. BCP05207
Name c-Kit-IN-1
Synonyms DCC-2618;DCC 2618;
SMILES
Chemical Name
Formula C₂₆H₂₁F₂N₅O₃ M. Wt 489.47
Purity 98% Storage Store at 4-8°C
Description DCC-2618 is a potent, orally active and selective KIT/PDGFR inhibitor with potential antineoplastic activity. DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. DCC-2618 also inhibits several other kinases, including vascular endothelial growth factor receptor type 2 (VEGFR2; KDR), angiopoietin-1 receptor (TIE2; TEK), PDGFR-beta and macrophage colony-stimulating factor 1 receptor (FMS; CSF1R), thereby further inhibiting tumor cell growth.
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