Cobimetinib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05208CAS No. ：934660-93-2Purity：98%

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CAS No.	934660-93-2	Cat. No.	BCP05208
Related Products	1369665-02-0（Cobimetinib hemifumarate）
Name	Cobimetinib
Synonyms	GDC-0973;XL-518;GDC 0973;XL 518;GDC0973;XL518;
SMILES
Chemical Name
Formula	C21H21F3IN3O2	M. Wt	531.31
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: The combination of GDC-0973 with the PI3K inhibitor GDC-0941 resulted in combination efficacy in vitro and in vivo via induction of biomarkers associated with apoptosis, including Bcl-2 family proapoptotic regulators . in vivo: The population rate constants associated with tumor growth inhibition for GDC-0973 and GDC-0941 were 0.00102 and 0000651 μM(-1) h(-1), respectively. Using the model based on single-agent and QD combination efficacy data, simulations adequately described the tumor growth from the Q3D combination regimen . Following single doses of GDC-0973, estimated in vivo IC(50) values of %pERK decrease based on tumor concentrations in xenograft mice were 0.78 (WM-266-4) and 0.52 μmol/L (A375).