Apalutamide New
Data Sheet
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| CAS No. | 956104-40-8 | Cat. No. | BCP05829 |
| Name | Apalutamide | ||
| Synonyms | ARN 509; ARN509;AR-509;JNJ56021927; JNJ-56021927;JNJ 56021927; | ||
| SMILES | O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F | ||
| Chemical Name | |||
| Formula | C21H15F4N5O2S | M. Wt | 477.43 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Apalutamide, also known as ARN-509 and JNJ-56021927 , is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells. | ||
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