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E7050 Chemical Structure

E7050

Data Sheet For research use only. Not for human use.
Cat. No. :BCP06122CAS No. :928037-13-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 928037-13-2 Cat. No. BCP06122
Name E7050
Synonyms Golvatinib;E-7050;E 7050;
SMILES O=C(NC1=CC=C(C=C1F)OC2=CC(NC(N3CCC(CC3)N4CCN(CC4)C)=O)=NC=C2)C5(CC5)C(NC6=CC=C(C=C6)F)=O
Chemical Name
Formula C33H37F2N7O4 M. Wt 633.69
Purity 98% Storage Store at 4-8°C
Description Golvatinib, also known as E7050, is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. c-Met/VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis.
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