AG-1024

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP06692CAS No. ：65678-07-1Purity：98%

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CAS No.	65678-07-1	Cat. No.	BCP06692
Name	AG-1024
Synonyms	AG 1024;AG1024; Tyrphostin AG 1024;
SMILES
Chemical Name
Formula	C14H13BrN2O	M. Wt	305.17
Purity	98%	Storage	Store at 4-8°C
Description	AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and restored pRb tumor suppressive function. Human breast cancer cell studies report AG1024 to induce apoptosis, inhibit cell proliferation, decrease bcl-2 and phospho-Akt1 expression, and elevate the expression levels of Bax, p53 and p21. Studies report AG1024 to block tyrosine kinase activity and to have a lower IC50 for IGF-1 in comparison to insulin receptors. Other studies indicate that exposure of SHR cells to AG1024 decreases Ang II-mediated NAD(P)H oxidase activation.