RITA
Data Sheet
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| CAS No. | 213261-59-7 | Cat. No. | BCP06744 |
| Name | RITA | ||
| Synonyms | p53 Activator III, RITA; NSC 652287; NSC-652287; NSC652287; Sos Bismethanol; | ||
| SMILES | OCC1=CC=C(C2=CC=C(C3=CC=C(CO)S3)O2)S1 | ||
| Chemical Name | |||
| Formula | C14H12O3S2 | M. Wt | 292.37 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | RITA (NSC 652287) is a DNA damaging agent with IC50 of 2 nM and 20 nM in A498 and TK-10 cells.Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo. | ||
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